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Generic Namehydrochlorothiazide and lisinoprilHYE droe KLOR oh THYE a zide Metformin treatment and lye SIN oh prilBrand NamesZestoretic.

If you have diabetesthis product may affect your blood sugarCheck your blood sugar regularly as directed and share the results with your doctorYour doctor may need to adjust your diabetes medicationexercise programor diet.

The potassium losing effect of thiazide diuretics is usually attenuated by the potassium conserving effect of lisinoprilThe use of potassium supplementspotassium-sparing agents or potassium-containing salt substitutes and other medicinal products that may increase serum potassium levelsparticularly in patients with impaired renal function or diabetes mellitusmay lead to a significant increase in serum potassiumIf concomitant use of lisinopril/hydrochlorothiazide and any of these agents is requiredthey should be used with caution and with frequent monitoring of serum potassiumsee section 4.4

Some hypertensive patients with no apparent pre-existing renal disease have developed usually minor and transient increases in blood urea and serum creatinine when lisinopril has been given concomitantly with a diuretic.

As with other ACE inhibitorslisinopril may be less effective in lowering blood pressure in black patients than in non-black patientspossibly because of a higher prevalence of low-renin states in the black hypertensive population.

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